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For Joints


  • Collagen as a bioactive ingredient that reduces joint pain.
  • Significantly reduce joint pain, and subjects with the greater deterioration benefit most.
  • Orally taken collagen peptides are accumulatedin cartilage as soon as 12 hours after the ingestionand the cells of the joint, the chondrocytes,are               responding to these extern collagen byproducing a dose-dependant production ofintern collagen.


In vivo studies were realized to evaluate the effect of ingesting collagen peptides as a dietary supplement.

The results showed that ingestion of collagen peptides directly improves joint mobility, comfort and reduces joint pain. In vitro studies reported that peptide molecules including prolyl-hydroxyproline (Pro-Hyp) and hydroxyprolyl-glycine (Hyp-Gly) are observed in the blood after ingestion of Collagen. These collagen peptides are accumulated in cartilage and help to repair joint matrix degeneration by stimulating chondrocytes cells for the biosynthesis of collagen.

As we age, our body loses its ability to make collagen and joints become stiff and less flexible.

Athletes are also effected by joint pain due to their intensive activity. Clinical studies have showed that Collagen significantly reduces joint pain and discomfort for an improved mobility by repairing joint matrix degeneration.


Study on Effects on Joint pain

Methodology: 24-Week prospective, randomized, placebo-controlled double-blind test study on the use of marine collagen hydrolysate as a dietary supplement. Athletes with activity-related joint pain were administrated collagen 10.000mg or placebo.

Observations: Joint pain at rest and for walking was considerably improved. Ingestion of collagen peptides directly improves joint mobility and comfort.




Osteoarthritis &ndash most common joint disorder is on the rise Collagen and joints

"insufficient amount of collagen results in the loss of cartilage. Without the normal amount of cartilage, the bones rub together, causing pain, inflammation and stiffness. Any movement can be extremely painful and mobility becomes limited."



ARTHRITIS WORLDWIDE. According to worldwide estimation, arthritis affects 9.6% of men and 18% of women agedover 60 years. Moreover, according to Datamonitor (2009), the arthritis prevalence has increased all over theworld since 2003, such as in India (+2.3% peryear) or Brazil (+2.1% per year), and will continue to grow, possibly even reaching 2.5% per year in India and 2.3% per year in Brazil.



For Bones,


comprehensive clinical studies showed that bioactive collagen helps to:

  •   Restore bone mineral density
  •   Collagen Peptide increases the bones size, making them less brittle
  •   Collagen Peptide Stimulates growth of bone. (It stimulates osteoblast activity in spite of osteoclasts activity)

Understanding Bone Health

Bone Problem can happen to anyone at any time.

In Random study conducted by Pasco and published in 2006 in Osteoporosis journal as determined that: 73.1% of fractures occurred in women without any prior bone problem


Osteoarthritis and osteopenia, two of the major health concerns, are among the leading causes of pain and disability. It is now well known that collagen peptides can help to maintain bone and Joint health to prevent osteopenia and osteoarthritis.











The main goal for screening and treating forosteopenia is to maintain bone health and preventfractures. It has been demonstrated that an early diagnosis and treatment of osteopenia reducesfractures rates and improves life quality.

In a recent Study atthe Physiology and Ingestive Behavior Laboratory,INRA-AgroParis Tech (Paris, France) and presentedbelow, confirm these scientific findings andprovide new information about the effect of Collagen Peptide on bone metabolism .


Study : Effects on Bone density in low protein condition

Methodology: Animal experiment to investigate the effects of collagen ingestion under low protein conditions. Mice were administrated collagen or casein.

Observations: The Bone mineral density was significantly higher for mice that were given food containing 6% casein + 4% collagen compared to mice given only 10% casein. These results suggest that collagen is superior to casein in its potential to enhance bone matrix and density.




LOSS OF MUSCLE MASSSarcopenia,or age-related loss of muscle mass, is linked toincreased body fat and reduced strength. Collagen peptidescan support muscleregeneration and preventmuscle loss.


If the amount of daily intake of protein is low, bone mineral density decreases. In addition, low protein conditions may be a cause of lower bone mineral density in the elderly. In vivo experimentation showed that Collagen helps to maintain bone health and restore bone mineral density.





Hydrolysate Protein Supplements on Nitrogen Balance and Body Composition in Older Women, Journal of the American Dietetic Association

Journal of Nutrition, 129: 1891-1895, 3 Oesser, S., et al., J., 2003, Stimulation of Type II Collagen Biosynthesis and Secretion in Bovine

Chondrocytes Cultured with Degraded Collagen, Cell Tissue Research, 311: 393-399 4 Guillerminet, F., et al., 2010, Collagen Peptides Improves Bone Metabolismand Biomechanical Parameters in Ovarietomized Mice: An In-Vitro and In Vivo Study, Bone. 5 Hays et al., 2009, Effects of Whey and Fortified Collagen

Jiang JX. et al., 2013 (in press), Peptan collagen peptides for treatment of knee osteoarthritis: A double-blind, randomized, placebo-controlled study

Nomura, Y., Oohashi, K., Watanabe, M. and Kasugai, S. 2005. Increase in bone mineral density through oral administration of shark gelatine to ovariectomized rats. Nutrition, 21:1120-1126.

Wu, J., Fujioka, M., Sugimoto, K., Mu, G. and Ishimi, Y. 2004. Assessment of effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature rats.

Journal of bone and mineral metabolism, 22: 547-553.

Karaguzel, G., Holick, M. 2010. Diagnosis and treatment of osteopenia. Rev Endocr Metab Disord, 11: 237-251.

Mizuno, M. and Kuboki, Y. 2001. Osteoblast-related gene expression of bone marrow cells during the osteoblastic differentiation induced by type I collagen.

Journal of biochemistry,129: 133-138.

Andrianarivo, A.G., Robinson, J.A., Mann, K.G. and Tracy R.P. 1992. Growth on type I collagen promotes expression of the osteoblastic phenotype in human osteosarcoma MG-63 cells.

Journal of cellular physiology, 153: 256-265.

Lynch, M.P., Stein, J.L., Stein, G.S. and Lian, J.B. 1995. The influence of type I collagen on the development and maintenance of the osteoblast phenotype in primary and passaged ratcalvarial osteoblasts: modification of expression of genes supporting cell growth, adhesion, and extracellular matrix mineralization. Experimental cell research, 216: 35-45.

Guillerminet, F., Beaupied, H., Fabien-Soulé, V., Tomé, D., Benhamou, C-L., Blachier, F., Roux, C. and Blais, A. 2010. collagen peptides improves bone metabolism and biomechanicalparameters in ovariectomized mice: an in vitro and in vivo study. Bone.

Moskowitz, R. 2000. Role of collagen hydrolysate in bone and joint disease. Seminars in arthritis and rheumatism, 30 (2): 87-99.

Ruiz-Benito, P., Camacho-Zambrano, M.M., Carrillo-Arcentales, J.N., Mestanza-Peralta, M.A., Vallejo-Flores, C.A., Vargas-Lopez, S.V., Villacis-Tamayo, R.A. and Zurita-Gavilanes, L.A.

Clark, K.L., Sebastianelli, W., Flechsenhar, K.R., Aukermann, D.F., Meza, F., Millard, R.L., Deitch, J.R., Sherbondy, P.S. and Albert, A.. 2008. 24-Week study on the use of collagenhydrolysate as a dietary supplement in athletes with activity-related joint pain. Current medical research and opinion, 24 (5): 1485-1496.

Oesser, S., Adam, M., Babel, W. and Seifert, J. 1999. Oral administration of 14C labelled gelatine hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL).

Journal of nutrition, 129: 1891-1895.

Oesser, S. and Seifert, J. 2003. Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen. Cell tissue research, 311: 393-399.

Pasco, J.A, Seeman, E., Henry M.J, Merriman, E.N, Nicholson, G.C, Kotowicz, M.A. 2006. The population burden of fractures originates in women with osteopenia, not osteoporosis.

Osteoporosis Int, 17: 1404-1409.









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